MCDB 418 Lecture Notes - Lecture 6: Progestin, Mifepristone, Cervix

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Ovulation: follicle ruptures & oocyte released into fallopian tube. Luteal phase: ovulated follicle forms corpus luteum: endocrine aspect, follicle, corpus luteum. Primordial follicle primary follicle development of oocyte/follicle continued development of follicle primary oocyte (graafian) secondary oocyte (mature follicle) Egg ruptures from follicle corpus luteum degenerating corpus luteum. Menstrual: primates, has period of menses; females always sexually receptive. Estrous: most others, no menses, females receptive only during period of estrus. (rabbit/cat) Gnrh neuron hypothalamus ap lh/fsh both positive on testis and ovaries. Testis (cid:314) testosterone (once released sends neg. feedback to neurons/ hypothalamus /anterior pituitary) Ovary (cid:314) estradiol and progesterone (once released sends negative feedback to neurons/hypothalamus /anterior pituitary) Lh and fsh affect ovarian function --proliferation, ovulation, steroidogenesis. Estrogen: biphasic effects (cid:314) lh surge (cid:314) ovulation. Progesterone: production by corpus luteum serves to: Inhibit lh secretion so another cycle won"t begin. Stimulates uterus to prepare for implantation of egg if pregnancy occurs.

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