MCDB 423 Lecture Notes - Lecture 6: Chromosome, Regulatory Sequence, Dna-Binding Domain

• School: U of M
• Department: Molecular, Cellular and Developmental Biology
• Course: MCDB 423
• Professor: John Kuwada

Document Summary

We discussed the dorsal ventral patterning in the previous lecture (and the paper we will read will continue this) What happens when cells see shh (things that will be discussed on the paper) No(cid:449) (cid:449)e"ll tu(cid:396)(cid:374) to patte(cid:396)(cid:374)i(cid:374)g of the a(cid:374)te(cid:396)io(cid:396) a(cid:374)d poste(cid:396)io(cid:396) a(cid:454)is. We"(cid:396)e go(cid:374)(cid:374)a (cid:272)o(cid:374)side(cid:396) just ap patte(cid:396)(cid:374)i(cid:374)g i(cid:374) the (cid:271)(cid:396)ai(cid:374) This is an early vertebrate brain and is patterned along the ap axis. In the most anterior portion, there is the telencephalon followed by the diencephalon and these two together make the forebrain. In the anterior end of the midbrain, there is the griseum tectalis (gt) which are just nucleus of cells. In the posterior, you get trochlear nucleus which are just motor neurons. The(cid:374) it"s follo(cid:449)ed (cid:271)(cid:455) the (cid:272)e(cid:396)e(cid:271)ellu(cid:373) a(cid:374)d the hi(cid:374)d(cid:271)(cid:396)ai(cid:374) There is a thin strip of cells that express a secreted protein called fgf8 (fibroblast growth factor) Prior to this type of axis, the nervous system is broken into the 3 sections (shown above)