MCDB 423 Lecture Notes - Lecture 32: Dlg4, Synapsin, Fibroblast

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There were 3 main kinds of alternatively spliced mrnas that were identified. 1 form called the y+z+ included 2 axons. The y and z axons are the inserts. Another form had the y but not z. A third where there was no y or z insert. He showed that proteins that were made from the y+z+ had aggregation activity but the other t(cid:449)o did(cid:374)"t. Since this is the case, the y+z+ must be specifically made by motor neurons and not muscles. Now you want to knockout the y+z+ agrin. What he did was he specifically formed a mutation that knocked out the z axon and thus you (cid:449)o(cid:374)"t ha(cid:448)e the y+)+ fo(cid:396)(cid:373) a(cid:374)(cid:455)(cid:373)o(cid:396)e. This had an affect on the motor axons as they are distributed in a wider portion but there are no achr clusters in the muscle. If (cid:455)ou looked at (cid:373)i(cid:272)e (cid:449)he(cid:396)e (cid:455)ou k(cid:374)o(cid:272)ked out the y a(cid:454)o(cid:374)s, the(cid:455) do(cid:374)"t ha(cid:448)e a(cid:374)(cid:455) agg(cid:396)egati(cid:374)g activity.

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