MCDB 423 Lecture Notes - Lecture 30: Fluorescence, Lipid Bilayer, Bassoon

• School: U of M
• Department: Molecular, Cellular and Developmental Biology
• Course: MCDB 423
• Professor: John Kuwada

Document Summary

Synapses are how neurons communicate with each other. An ap will come down the axon, invade the presynaptic terminal and depolarizes the membrane. This increase causes fusion of the vesicles to the terminal. Nts bind to receptors on post synaptic membrane. When bound by nt, they open and allow ions to flow through. Most of the synaptic vesicles are all the same size. Synaptic vesicles are clustered around the dark patches. Da(cid:396)k (cid:373)ea(cid:374)s the(cid:396)e"s lot of p(cid:396)otei(cid:374)s of su(cid:271)st(cid:396)ates that a(cid:396)e ele(cid:272)t(cid:396)o(cid:374) de(cid:374)se i(cid:374) a(cid:374) ele(cid:272)t(cid:396)o(cid:374) micrograph. On the pre-s(cid:455)(cid:374)apti(cid:272) side, the(cid:455)"(cid:396)e (cid:272)alled active zones where ca channels reside and many synaptic vesicles are already docked. On the post synaptic side, you can see dark densitites which are the collection of nt receptors. The latency is for the time it takes for the nts to fuse to receptors and the time it takes to travel through the cleft.