PSYCH 270 Lecture Notes - Opioid, Cirrhosis, Naltrexone
Document Summary
Our system adapts so that higher quantities of drugs are needed to get the same effect. Metabolic: the liver becomes more adapt at processing the drugs, so more is needed, alcohol tolerance. Pharamacodynamic: regulation occurs receptors adapt to overexposure to the neurotransmitter, cocaine tolerance, increase dopamine levels, down regulates the dopamine. Severe physiological symptoms that occur after stopping drug intake. Alcohol: enhances gaba transmission, enhances inhibition, gaba adapts, becomes less responsive, alcohol withdrawal seizures, behavior. Drug seeking behaviors: spending significant amounts of time looking for drugs. Continued use despite physical consequences: cirrhosis of the liver, dsm allows for all drugs but caffeine, treatments, substitution. Methadone: opioid that blocks cravings, suppresses withdrawal, minimal euphoria, blocks effects of other opioids, after entering methadone programs, crime days decrease significantly, prevention/antagonistic. Prevents the drug from having an effect. Naltrexone: blocks opioid receptors, preventing high, aversive therapy. Makes you feel sick after drinking: motivational interview.
