Biological Membranes, Fluid Mosaic Model, Membrane Proteins

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Biochemistry & Molecular Bio.
David Gross

Feb 28 Notes • central dogma of molecular biology o DNA– RNA– protein • protein compartmentalization is key level of cellular control o cellular control levels:  transcription  post-transcription  translation  post-translation  localization (within cell)  quality control • structure & properties of biological membranes o lipid bilayer  classes of membrane lipids  formation of micelles & bilayers  biological membrane dynamics o membrane proteins  classes of membrane proteins  structural features of membrane proteins  membrane protein dynamics o membranes as semi- & selectively permeable barriers  membrane permeability  membrane transport  membrane electrochemical potential • modified fluid mosaic model o lateral diffusion of membrane proteins can be restricted by interactions w/ cytosolic structures (cytoskeleton) • membranes are semi- & selectively permeable o hydrophobic molecules (O2, CO2, N2, steroids, hormones) pass through freely o small uncharged polar molecules (H2O, urea, glycerol) some pass freely through o large uncharged polar molecules (glucose, sucrose) size restricted passage, need assistance o ions (H+, Na+, HCO-, K+, Ca2+, Cl-, Mg2+) don’t pass through membrane w/o assistance • basis of membrane electrochemical potentials o this is a chemical concentration gradient o the elec
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