BIOCHEM 523 Lecture Notes - Lecture 13: Ionophore, Membrane Potential, Cyclic Peptide

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Maintaining a membrane potential (if the substance is ionic) The rate of non mediated transport across lipid membranes is faster for nonpolar. The rate of non mediated transport is substances. C2 and c1 are concentrations of the substance on either side of the membrane. Water can diffuse across the membrane or go through membrane-spanning channels. Facilitated transport, through pores, permeases, or carriers, can increase the rate of called aquaporins diffusion across a membrane by many orders of magnitude. Facilitated transport can be passive or active. Passive transport can only achieve net transport of a substrate along its. Active transport can move a substrate against its concentration gradient, but this concentration gradient requires an input of free energy. Ionophores increase the permeability of a cell membrane to ions. Bacteria secrete ionophores that act as chemical warfare agents, or antibiotics. Valinomycin, an antibiotic cyclic peptide that facilitates the transport of k+

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