BIOCHEM 523 Lecture 16: Glycolysis Regulation and Other Sugar Pathways
1 Jan 2018
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Biochem423/523 - lecture 16 - glycolysis regulation and other sugar pathways. Gluconeogenesis is the synthesis of glucose from noncarbohydrate precursors. Synthesis of glucose from noncarbohydrate precursors is essential for the maintenance of blood glucose levels within acceptable limits. Tissues from the liver and kidney cortexes synthesis glucose. Tissues from the brain, nervous tissue, muscle, kidney medulla, erythrocytes, and testes use glucose as their primary energy source generally non-carbohydrate in nature glycolysis. The biosynthetic process of gluconeogenesis starts with three to four carbon precursors, Gluconeogenesis uses specific enzymes to bypass three irreversible reactions of. The remaining seven reactions of gluconeogenesis are reversible because they are all. Three bypasses allow the two pathways to co-exist in the same cell near equilibrium under cellular conditions. The bypass of pyruvate begins in the mitochondrion. Pyruvate carboxylase catalyzes atp and biotin dependent carboxylation of pyruvate to oxaloacetate. The enzyme requires acetyl-coa as an allosteric activator.
