BIOLOGY 152 Lecture Notes - Lecture 1: Passive Transport, Flippase, Facilitated Diffusion

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Fluidity: individual molecules remain in close association yet have the ability to readily move within the membrane. Semifluid: most lipids can rotate freely around their long axes and move laterally within the membrane leaflet. (cid:862)flipflop(cid:863) of lipids fro(cid:373) o(cid:374)e leaflet to the opposite leaflet does (cid:374)ot occur spontaneously. Flippase requires atp to transport lipids from one leaflet to another. Depending on the cell type, 10-70% of membrane proteins may be restricted in their movement. Integral membrane proteins may be bound to components of the cytoskeleton, which restricts the proteins from moving laterally. Also membrane proteins may be attached to molecules that are outside the cell, such as the interconnected network of proteins that forms the extracellular matrix. Passive transport does not require an input of energy. Passive diffusion: diffusion of a solute through a membrane without transport protein. Facilitated diffusion: diffusion of a solute through a membrane with the aid of a transport protein.

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