BIOL 208 Lecture Notes - Lecture 3: Macrophage, Mononuclear Phagocyte System, Transferrin

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4 Feb 2017
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Anatomy lecture 3
Causes of hypoxia:
- hypoxia is due to poor oxygen delivery
- anemia - lack of oxygen ability to provide blood
-low blood cell count
- hemorrhage- lose 1 liter of blood
-body can extract fluids
-lack of sufficient iron in hemoglobin
-structural defects such as sickle cell anemia
- increased levels of activity
-athletes have higher blood count
-high altitude
-% of oxygen does not change, pressure changes
Hemoglobin
-no oxygen attached- deoxyhemoglobin
-oxygen attached- oxyhemoglobin
-oxygenation- when oxygen attaches to hb --- oxyhb--- unloads oxygen in tissues
deoxyhb or reduced hb- no oxygen
Hb and Co2 transport
- co2 transported as blood
- 7% dissolved in plasma
- 23% on hb
- 70% in HCO3- (bycarbonate ion)
- co2 attaches to globin instead of Fe (iron)
- HBCO2 - carbaminoHb
- Co2 attaches to Hb in reduced state
- oxygen is gone
- 2 hemoglobin forms: Met-Hb and CarboxyHb
- Fe++ is ferous state
- Fe+++ is oxydized state- can’t function
Erythrocyte degradation
- membrane structures fall apart
- macrophages - recycle old tissues
- everywhere in body
- macrophage system (reticuloendothelial)
-make up capillary wall
-breakdown RBCs
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