BIOL 208 Lecture Notes - Lecture 7: Fibrinogen, Thromboplastin, Haemophilia
25 Feb 2017
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Platelets can"t clot and results in imperfect wbcs, rbcs, and platelets. People die from internal hemorrhage or chronic devastating infection. Epstein - virus: large b-lymphocytes and greater numbers. Not cells and have granules in them. Occurs at arterial - smooth muscle contracts. Major artery affected- will vasoconstrict and diminished blood loss. Reduces blood flow and lasts 20 to 30 minutes. Platelet plug: injury to lining of vessel exposes collagen fibers; platelets adhere. Release chemical - makes nearby platelets sticky. Fibrin forms mesh - traps rbcs, wbcs, and platelets. Activated in damaged area and in a series. Hemophilia occurs if procoagulant and anticoagulant are missing. Factor 3) tissues thromboplastin- produced by damaged tissue. Pf3 - needed in intrinsic and common pathways. Platelets stick, attach to endothelium leading to tissues. Activate factor 10 which activates 9 and 8. Tissues cut and damaged - cells damaged too. Activated 10 activates 5 which activates pf3 which activates calcium.
