CHEM 2312H Lecture Notes - Lecture 1: Human Development Index, Enol, Nucleophile
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Both compounds would go into the ether layer, but some of the amine would go into the water. Ochem lab page 1 it would be hard to add oh to this one but the top one gets hydrolized easier. Saturated h2o nahco3 acidify bicarbonate layer w/ 10% hcl ph <= 3. X will be protonated and want to go back into ether layer. An enol ester the carbonyl doesn"t have as much donation from ester. -> nucleophile can attack better alcohol held near carbonyl in active site kinetic resolution. 0% don"t use stir bar for this rxn b/c stir bar can crush enzyme and denature it instead, use neutator which rocks culture tube rxn vessel. Synthetic communications: an international journal for rapic communication of synthetic organic chemistry improved chiral synthesis of ravuconaxole. Lin xu, marc r. muller, xiong yu et bao-quan.
