Lecture 3122014.pdf

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Department
Chemistry
Course
CHEM 2332H
Professor
Christopher J.Douglas
Semester
Spring

Description
Lecture 3122014Wednesday March 12 2014852 AMAminesOn your own Spectroscopy and Iminessubstitution on analine andpyridinesamine nucleophiles in substituion sn2 acylation sulfonylationSubstitution on aromatic aminesthe lone pair on N is a good nucleophilefor halogenation add sacrifical baseEnhances rxn and prevents problem wBut not always workssacrificial base wont work if have strong protic acid as reagent HNOHSO324 will cause rxn to volcano on youalso wont work w strong Lewis Acid AlCl no FriedelCrafts3Pyridine relative to benzene pyridines much slower to undergo electrophilic aromatic substitution EAStends to go meta relative to N on pyridine Ochem Page 1
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