Lecture 4182014.pdf

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Department
Chemistry
Course
CHEM 2332H
Professor
Christopher J.Douglas
Semester
Spring

Description
Lecture 4182014Friday April 18 2014856 AMTodayCarbamate Protecting Groups Handout example peptide synthesisCondensationsalphaSubstitution of carbonyl compounds Ch 22 Review EnolEnolate alphaSubstituion IntroCh 22 problems in Notes Problem Set Due MondayCHallenge incompatible functional groupsPhenyl analineLysineMaking tripeptidestripeptide 1 lysine2 phenyl alanineVery tough to removeneed very strong base water high T for nucleophilic substitutionbut not good for working w amino acids not used in peptides Ochem Page 1
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