LAMP 4177 Lecture Notes - Lecture 1: Tissue Factor Pathway Inhibitor, Dermatan Sulfate, Von Willebrand Factor
4 Apr 2016
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Document Summary
Hemostasis: a physiologic process to prevent bleeding when a blood vessel is damaged,a dn at the same time, keep blood in a fluid state. -many checks and balances that keep this in control. -involves: fibrin formation by coagulation system: blood vessels and supporting structures, platelets. 6. fibrinolytic system remodeling and repair of injury. -steps of hemostasis: primary- platelet plug formation, secondary- coagulation system. -anticoagulant properties on the surface to prevent clotting. -no good laboratory tests for endothelial cell function: platelets. -platelet function= contact, adhesion, aggregation and release: von willebrand factor. -mediates platelet adhesion at sites of vascular injury protects and binds factor viii(8) **recognition of damaged endothelium adhesion aggregation coagulation. A series of enzymatic steps to actually make the fibrin clot. Coagulation factors and inhibitors keep us in balance: factors: -vitamin k dependent factors ii, vii, ix, x, protein c + s. -certain drugs like warfarin, blocks the ability for these factors to become activated.
