PHSL 3051 Lecture Notes - Lecture 37: Lipolysis, Deamination, Hypothalamus
Document Summary
All tissues except for brain begin to oxidize triglycerides for energy. Brain runs almost exclusively on glucose and ketone bodies (under extreme conditions) supplied by the liver. Liver is responsible for making glucose - primarily from muscle breakdown. Metabolic pathway that generates glucose molecules from the breakdown or hydrolysis of glycogen. Metabolic pathway that results in the generation of glucose from non- carbohydrate carbon substrates. Deamination of amino acids into keto-bodies (into glucose) and ammonia. Adipose lipids become free fatty acids and glycerol that enter blood. All other tissues (except brain) oxidize fatty acids to make atp. People die due to lack of muscle that can be converted into glucose for the brain! Muscle glycogen can be used for energy. Muscles also use fatty acids and break down their proteins to amino acids that enter the blood. Breaks down glycogen into pyruvate or lactate. Brain can only use glucose and ketone bodies for energy!
