BIOL 4220 Lecture Notes - Lecture 5: Olfactory Tubercle, Extrapyramidal System, Sympathomimetic Drug
Document Summary
Post-synaptic effects of amph: in striatum (bg) Increase transcription of gene that encodes for substance p (pain transmission) Phosphorylation of transcription factor: induction of c-fos by amph. But no effects in mesolimbic system (nacc, olfactory tubercle: no long term effect on behavioral reinforcement. At low dose: increase locomotion (bg, but no focused stereotypies. Stereotypy: stereotypical sniffing in rats (expy, purposeless pacing. At high dose: increase stereotypic sniffing, increase purposeless pacing, increase glucose metabolism. Sympathomimetic effects (fight-or-flight response: increase alertness, increase vigilance, increase attention, increase focus, increase energy, decrease appetite, increase motor performance (gross motor skills) Med dose (20-50 mg: stim respiration, increase slight tremor, increase restlessness, increase agitation, increase insomnia. High dose (> 50 mg: increase stereotypy, sudden outburst of aggression, paranoia psychosis, weight loss (appetite suppressant) Dependence and tolerance: psychomotor behavioral stimulation, prone to compulsive use. Withdrawal symptoms: rebound effects, increase appetite, increase weight (gain, decrease energy, increase need for sleep. Tolerance to euphoria: lead to accelerated use.
