BIOL 4220 Lecture Notes - Lecture 3: Nicotinic Acetylcholine Receptor, Gabab Receptor, Anticonvulsant
Document Summary
Gaba (gamma amino butyric acid: inhibitory nt, found everywhere in cns, conc in amygdala (fear & anxiety) Opens cl- channel only when gaba is bo. Progesterone is reproductive hormone r phase of menstrual cycle. Decrease in serotonin level: depression, irritability, aggressive, lack of emotions or emotional response (inappropri, social emotions. Prozac , zoloft, etc: maoi (monoamine oxidase inhibitor) Enhance the nt at synapse b/c blocks the. Side-effects esp. acts on ach system: mdma (5,7-methylenedioxymethamphetamine) Blocker (blocks the contractility of the heart m: awaking up the cortex (originate in brainstem, amphetamine (stim release of da & ne, w/o ne, the cortex cannot be waken up, => coma. D1, d2, d3, d4, d5 receptor (inhibitory: mesolimbic system (dopaminergic system) Dopamine (da: cocaine (block da reuptake transporter) Insensitive to d2-receptor: amphetamine (stim release of da) Reinforce behavior: adhd/add (attention deficit hyperactivity disorder) Unable to focus (suppressing attention to othe stim) Drd4-gene encode for d4-receptor (drd4 = do receptor d4)