BIOL 4220 Lecture Notes - Lecture 7: Medial Forebrain Bundle, Tricyclic Antidepressant, Biogenic Amine
Document Summary
Pag => periaquaductal gray ( in brainstem: gating pain. Depression: biogenic amine hypothesis, hypofunction of 5-ht, anti-depressant targeting 5-ht system, newer antidepresant. Lift depressant instant within 4 hr of injection. Action on 5-ht but also ne or da. Requires 4-6 week for therapeutic effects to kick in. Byproduct of breaking down pcp, ketamine => active ingredient => Prodrug => no action by itself => but once inside the system => metabolize it => endproduct is the active ingredient. 5-ht system: promote well being of animals, promote mood state that is calming and safe, infants dependent on maternal care, releasing 5-ht in both mother and infant => bond => sense of secure and safety. Anxiety becomes non-issue: separation anxiety if mother is not around to comfort you, lose the sense of security and safety, lead to anxiety (gad) generalized anxiety disorder, treat cause of anxiety, treatment for anxiety. Flush out vesicular content of 5-ht into cyto then into synapse.
