BIOC 3110 Lecture Notes - Lecture 27: Dihydroxyacetone, Acyl Coa Dehydrogenase, Lysine

• School: University of Iowa
• Department: Biochemistry
• Course: BIOC 3110
• Professor: marcwold

Document Summary

3 stages of fatty acid processing: 1. Degrade triacylglycerol to release fatty acids and glycerol into the blood for transport to energy requiring tissues breaking from lipid droplet: 2. Activation of fatty acid and movement into mitochondria: 3. Degradation of fatty acid into acetyl coa by beta-oxidation for processing by citric acid cycle. Signal cascade that signals fatty acid degradation. Epinephrine and glucagon (saying not enough glucose, need to breakdown lipids) bind to 7tm receptor on adipocyte cell. Camp is signaled, activating protein kinase a, which phosphorylates 2 things: Perilipin-protein sitting around lipid droplet; when activated by phosphorylation, it swings out and activates a series of lipases, and gives access to inside of lipid droplet: once phosphorylated, perilipin activates. Atglipase, which removes the first fatty acid off, to form a diacylglyceride and a free fatty acid. Hormone-sensitive lipase-when phosphorylated, removes another fatty acid, to release monoacylglyceride and another free fatty acid.