HHP 3500 Lecture Notes - Lecture 40: Inulin, Creatinine, Nephron

• School: University of Iowa
• Department: Health and Human Physiology
• Course: HHP 3500
• Professor: Peterson Clayton

Document Summary

Overview of renal processes: glomerular filtration-fluid and ion moving from capillaries into bowman"s capsule via bulk flow to form pre-urine. Everything filters except for cells and plasma proteins. This value is determined by net filtration pressure, and solute permeability. Filtrated by bulk flow, and hydrostatic pressure favors filtration, whereas osmotic force favors secretion; net pressure = 16 (note why larger net pressure than systemic capillary beds) Gfr is highly regulated: mainly regulated by changing globelmular pressure, can constrict downstream efferent arterial, which could increase pressure, or, can dilate the afferent arterial to increase pressure, can also regulate the gfr cell leakiness. Filtered load: gfr filtration rate * plasma concentration of specific filtrate; ex. Glucose: filtered load = 180 l /day * 1g/l = 180 g glucose/day that ends up in filtrate: secretion-movement from peritubular capillaries into renal tubule, reabsorption- movement from renal tubule into peritublar, excretion = filtration + secretion reabsorption.