NRS 313 Lecture Notes - Lecture 8: Weight-Bearing, Clastic Rock, Osteoclast
27 May 2018
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Pre Lecture Video Notes - Bone
• Afferent and efferent messages
o Afferent sensory nerve messages: send messages associated with pain and touch or
vibration. From P up to the afferent pathway to cerebrum where they are interpreted by
the brain.
o Through the dorsal horn. Upward to the brain where the message is perceived. Then
you will want to withdraw from the pain
o The message is sent back down through the efferent messages.
o They go through the ventral horn. They control skeletal muscle responses.
• Outer most layer that is protecting the spinal fluid in the spinal cord is the dura layer
o The next layer is arachnoid layer
o The next layer is the pia layer.
o The spinal fluid is in the sub arachnoid space.
• Contusion or laceration of spinal cord and epidurals
• Epidurals: located in the epidural space. Insert needle with a catheter. The needle then comes
out.
o Will bath the afferent and efferent nerve fibers
o Analgesic: pain medicine
o Anesthetic: causes numbness below where the epidural is.
o Not a high risk of spinal fluid leak
• A spinal anesthetic.
o Put into the arachnoid space where spinal fluid is. This is will provide both anesthetic
and analgesic except this medicine is being infused into a different area
o Difference is 1. The location and 2. Its use
o Epidurals have indwelling catheter whereas the spinal anasethic, there is just fluid
injected
• Bone formation
o Osteoblast: bone formation. Lay down new bone
▪ Reklease rank ligand
o Osteoclast: bone resorbtion. Reforming or reabsorbing bone. Releases Ca ++ in blood
stream
• Rank Ligand
o Purpose is to attach to protein receptor.
o Attaches to Rank receptors on osteoclasts
o When they connect, it activates the osteoclast to come down and reabsorb bone
• Osteoprotegrin
o Acting like a decoy for rank ligand
o Osteoprotegrin also relased by osteoblasts. When the osteoblast releases
osteoprotegrin it acts like a decoy
o OPG attaches to rank ligand causeing rank ligand to think it has attached to the rank
receptor
o We need these decoys because we need both times when the bone is absorbed and
formation
find more resources at oneclass.com
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Document Summary
Pre lecture video notes - bone: afferent and efferent messages, afferent sensory nerve messages: send messages associated with pain and touch or vibration. From p up to the afferent pathway to cerebrum where they are interpreted by the brain: through the dorsal horn. Upward to the brain where the message is perceived. Then you will want to withdraw from the pain: the message is sent back down through the efferent messages, they go through the ventral horn. This is will provide both anesthetic and analgesic except this medicine is being infused into a different area: difference is 1. Its use: epidurals have indwelling catheter whereas the spinal anasethic, there is just fluid injected, bone formation, osteoblast: bone formation. Lay down new bone: reklease rank ligand, osteoclast: bone resorbtion. Releases parathyroid hormone: enters blood stream and goes and fiens an osteoblast.
