BIOL 483 Lecture Notes - Lecture 61: Histone Deacetylase, Chromosome, Xist (Gene)

22 views2 pages
School
Department
Course
Professor

Document Summary

For regulation, rna and dna can be modified (eg. methylation: m1a, m6a, m1g) > most common modification in rna = m6a lncrna. > imprinting: acts in cis to silence maternal/ paternal allele. > x inactivation: acts in cis to silence particular chromsome. Acts in cis to cause epigenetic/ chromatin silencing. > in cis = regulates transcription of neighbouring genes on same chromosome. Eg. calico cat - clone copycat has different coat pattern from mum because gene is on. X chromosome, coat pattern depends on which x chromosome is activated. At any time, only 1 x chromosome can be active - same dosage in both males and females. After fertilisation/ before implantation, females have double dosage of x -> no silencing. After implantation, both maternal and paternal chromosome that is inherited gets partially silenced -> equal dosage. Many different ncrnas involved (eg. xist, tsix, xce) > mutation in xic -> no x inactivation.

Get access

Grade+
$40 USD/m
Billed monthly
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers

Related Documents