BIOL 483 Lecture Notes - Lecture 63: Chromatin, Growth Factor, Chromosome

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Act in cis = can regulate transcription of neighbouring genes in same chromosome/ act on same allele. > provides precise allelic address that allows lncrna to tether at site by pol ii. > rapid turnover/ additional tethering prevents diffusion to 2nd allele. Act in trans = can regulate transcription of genes between chromosomes/ go between allelels. Arabidopsis has >40k lncrnas, 25k protein coding genes. Humans have 65k lncrna, 23k protein coding genes. Economical - needs transcription but no translation needed. Very specific since they have longer stretches of dna. > tf binding sites 6-16 nucleotides, lncrna > 200bp. > advantage over tf for recruitment since high specificity by annealing dna over some but not whole genome. Xic = x inactivation centre, involved in choice of which x chromosome gets inactivated and counting to determine how many x chromosomes need to be inactivated.

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