BIOL 483 Lecture Notes - Lecture 79: Stoichiometry, Chromatin, Protein Structure

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All biological material is compartmentalised (most obvious with cells - cell inside and outside different) Cell surrounded by lipid membranes and many intracellular organelles that are surrounded by lipid membranes to allow for different molecular composition inside vs outside - important for biochemical processes. Can organise macromolecules in this way - function is like with organelles (concentrating molecules and separating them, but nature of condensates and underlying mechanisms differ. Known that cells have many membraneless compartments (biomolecular condensates) Sometimes they"re highly dense structures in cell or nucleus, but most easily visaulised if you look at core components (immunofluroescence -> highly condensed region and protein forms big blog of stuff from cytoplasm) Fundamental discovery or new idea is thought that condesnates can form through phase separation. Phase sep = demixing transition, condensed can coexist with dilute phase 9like how oil can exist with water without mixing)

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