BIOL 522 Lecture Notes - Lecture 12: 1000 Genomes Project, Haplotype, Zygosity
Document Summary
Haplotype = group of alleles that have been inherited from a single parent. Expectation maximisation algorithm used to improve haplotype estimation results. Rfmix = powerful discriminating sample, autocrorect errors in haplotype phasing. Tracts = set of classes used to model migration histories on the basis of ancestry tracts in admixed populations. Pole genome micrornas identify human genome susceptibility regions. N = number of individuals, d = number of features that correspond to genetic variant (ancestry specific. Subcontinetnal diversity and origins in recently admixed american populations. Ref panel = native american, afircan, and european populations. Middle/ bottom population = different populations of african ammericans and hispanics, and show amount of admixture from african/ ueropean/ native american components respectively in those populations. In the top panel, each three groups is a solid block is because they"re the reference panels, assume that they represent a single common ancestry pool, but doesn"t tell us how admixed, similar, different indiiduals are.
