BPS 432 Lecture Notes - Lecture 40: Μ-Opioid Receptor, Nmda Receptor Antagonist, Opioid Receptor
6 Feb 2017
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Document Summary
During injury, first (fast) and second (slow) pain responses based on axon diameter. Local anesthetics i. e. lidocaine blocks intracellular side of vasc: perception: integration of all nociceptive impulses and interpretation. Brain structures involved: reticular formation, thalamus, hypothalamus, limbic system, cerebral cortex. Opioids, alpha 2 agonists or distraction, relaxation, behavioral: modulation. Descending inhibition: nervous impulses travel down the spinal cord and release serotonin, ne, and endogenous opioids, which reduce the nociceptive transmissions/pain. Nociceptive: arises from nerve terminals responsibly fro nonciception, firing appropriately due to injury or inflammation of a body structure. Non-nociceptive: die to pathological functioning of the nervous system. Neuropathic: source of pain is injury of irritation to peripheral nerves. Central: pain associated with cns disease; damage to the spinothalamocortical tract or abnormal alternation of the central pain receiving circuit. Presynaptically: inhibit voltage gated ca channels less release of glutamate. Post-synaptically: activate voltage gated k channels hyperpolarize post-synaptic membrane less likely to generate an action potential.
