NUR 234 Lecture Notes - Lecture 4: Portal Vein, Cardiac Output, Molecular Mass

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11 Apr 2016
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Determined by these 3 factors: blood flow to tissues, exiting the vascular system, entering cells. Arterial disease, liver disease, decreased cardiac output- blood flow might be as good (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Need to be careful w/ meds if u have prob w kidney / liver. We want our drug to be lipid soluble to be absorbed blood-brain barrier. Tight junctions between the cells that comprise the walls of most capillaries in the central nervous system. Drugs must be able to pass through the cells of the capillary wall. Only drugs that are lipid soluble or that have a transport system can cross the blood-brain barrier to a significant degree: very lipid soluble = very good transport, if water soluble = not good (cid:1) (cid:1) Tight junctions between cells that comprise the walls of capillaries in the cns prevent drugs from passing between cells to exit the vascular system.

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