BISC 220Lg Lecture Notes - Lecture 11: Cyclin-Dependent Kinase, Sister Chromatids, Spindle Apparatus
6 Apr 2017
School
Department
Course
Professor
Document Summary
On the exam: the material needed is the material talked about in class. Have a couple different kinases, has a specific complex called mpf. Cyclin dependent kinase adds phosphate to a bunch of proteins that allows cyclin to go through to the next phase. The cyclin dependent kinase is activated by cyclin, Concentrations of cyclin varies across different cellular phase. Complex can go off and do what it needs to do. Kinase amount stays the same, but activity varies across cycle. Squeezing single strand of dna into one chromosome. G0, g1, entry to s = 1 copy. Exit from s phase, g2, m phase to cytokinesis: 2 copies. Exit from cytokinesis: two separated copies of genes. A chromosome when replicated become sister chromatids. After s phase: dna is replicated, centrosome replicated. Centrosome replication controlled by cdk complex where the concentration peaks at the g1-s transition (key event in directing cell towards mitosis) Followed by cytokinesis which is the actual division.
