BIO 370 Lecture Notes - Lecture 3: Lactose Intolerance, Peppered Moth, Lactase Persistence

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27 Sep 2018
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Horned lizards: longer horn length = higher expected survival from the shrike: ex. Haldane: measures speed of evolution by natural selection = spread of an advantageous mutation: positive selection: when one allele has higher fitness. Peppered moth: result of 1 allele change: melanic allele: 1st detected in 1848, haldane measured s = 0. 5, ex. Lactose tolerance: e(cid:448)ol(cid:448)ed i(cid:374) europe a(cid:271)out (cid:1005)(cid:1004),(cid:1004)(cid:1004)(cid:1004) (cid:455)/a. I(cid:374) (cid:272)ultures that do(cid:374)"t rely on much lactose, the gene is turned off = lactose intolerant: ex. Light skin color allele spread by positive selection 50,000 y/a: slc24a5 allele for light skin color. Europe (cid:449)here there"s little su(cid:374)light = de(cid:272)reased (cid:448)ita(cid:373)i(cid:374) d to (cid:272)o(cid:373)(cid:271)at less. Uv light, but more likely to get cancer (very rare in tropical regions): overdominance: when heterozygotes have highest fitness. Hemoglobin: rbc sickled shape = immune to malaria, but decreases o2 tra(cid:374)sport to (cid:271)od(cid:455).

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