NEU 365T Lecture Notes - Lecture 14: Electroconvulsive Therapy, Neurotrophic Factors, Retrograde Amnesia
Document Summary
Stress elevation of glucocorticoids down-regulation of bdnf atrophy & damage of hippocampal neurons reduction of hippocampal feedback inhibition of the hpa axis more glucocorticoids depression. Antidepressant increase 5-ht & ne transmission activation of camp-creb cascade increased expression of bdnf increased growth and function of hippocampal neurons increase in hippocampal feedback inhibition of hpa axis relief of depression. Bdnf repair stress-induced damage to hippocampal neurons + protect vulnerable neurons from further damage. Treatments for mood disorders: ect (electroconvulsive therapy) - most effective treatment. Rapid relief of symptoms (first choice when suicide risk is high) Good when all other antidepressants aren"t working. Can induce hippocampal neurogenesis in rodents (likely via neurotrophic factors: bdnf, etc. ) Usually disrupts memories of events that occurred before treatment (extending back 6 months on average) Phobia - acute exposure therapy & extinction therapy - anxiety disorders. Not known if increases bdnf in hippocampus: exercise. Enhances hippocampal bdnf expression and neurogenesis: antidepressants.
