NEU 365W Lecture Notes - Lecture 10: Stimulant, Nootropic, Cognitive Flexibility
Document Summary
Arousal, alertness, vigilance, increased performance, cognitive enhancers, focus. 1908 - yerkes-dodson law and the inverted u-shaped curve -mental task. Physical task - also possible u-shaped but right-shifted. Too high a dose - too aroused to do mental tasks. 1954 - schlosberg level of activation on a continuum . 1975 - lyon & robbins: increasing stimulatory effect = increasing response rates within a decreasing number of response categories . Cocaine (amount of exposure or of repeated exposure) - video of rat behavior. Humans: (1) psychomotor stimulant effect that can be stereotypic (2) craving (wanting) (3) psychotomimetic effects (amphetamine psychosis) Tolerance decrease in some behaviors (since it requires more) Humans: (1) most autonomic effects (2) anorectic effects (3) euphoria (liking) Side effects of repeated administration (1) tics (2) psychomimetic effects (3) addiction. Pharmacokinetics -how a body processes a drug: absorption, distribution, metabolism drug, and elimination ([drug] based) The duration of action of a drug is known as its half life.
