NEU 365W Lecture Notes - Lecture 18: Methamphetamine, Institute For Operations Research And The Management Sciences, Naltrexone
Document Summary
Rosetta stone approach: multiple models (study different aspects of the different disorders) Comparison with reference compounds: info from lab studies validate animal models, addiction field: these translate well (lots of cross translation) Drugs cross maybe a few stages & animal models and cross to human. Neuroanatomy of the 3 stages of addiction models: 1. ) Existing meds interrupt (acute) effects of drugs block receptors, make them aversive (disulfiram), mimic activation of receptors (block use of illicit substance) Future meds: develop partial agonists (bind drugs of abuse) & vaccines to absorb the drugs and prevent them from getting to the brain: 2. ) Extended amygdala, bed nucleus of the stria terminalis, parts of nac. Future meds: what are the neuroadaptive occurrences in the host & counteract those mechanisms. Ex: crf1 antagonists levels & activity increase with chronic drug use (none have worked well in human trials yet), kappa-opioid antagonists, Gaba modulators (restore gaba signaling that is downregulated in chronic alcohol administration: 3. )
