ANSC 380 Lecture Notes - Lecture 3: Chemotaxis, Macrophage, Collagen
Document Summary
Animal science 380: three different levels of defense mechanisms. Increase peristalsis: urogenital tract, flushing effect, acidic ph. Innate immunity: phagocytes, phagocytosis, swallowing of a cell, cells that are adapted to engulf and destroy microbes or foreign particles, natural killer cells. Infected host cells are eliminated by apoptosis: both of these are non-specific and can cause tissue damage, phagocytes, neutrophils, present in larger numbers and are the initial responder during an infection. Leave the blood stream to go to different tissues and mature into macrophages: macrophages, cytokines and chemokines, chemotaxis aka chemical signals. Inflammation: clinical signs, redness, swelling, heat, pain, signs develop due to cytokines/phagocyte activation, tissue damage stimulates mast cells, histamine release, blood vessels become leaky. Injured tissue is replaced with connective tissue and produces a scare which leads to a less flexible organ etc: causes fibrosis, adaptive immunity, complex, has memory, specific, requires initial encounter, two types, humoral, antibody mediated, cell mediated.