BCMB 230 Lecture Notes - Lecture 11: Myelin, Schwann Cell, Blood Vessel

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Stimulation of a dendrite that is strong enough creates an action potential along an axon. Resting potential: more na+ on outside more k+ on inside of cell. It creates a charge where the outside is more positive than the inside. Membrane is much more permeable to k+ than it is to na+ Sodium atpase is moving sodium against its gradient. Because of all of this we have more k+ moving out than na+ moving in. This establishes an eq. where outside is positive and inside is negative. Any ion movement can influence charge across the cell. Cell becomes closer to 0= na+ in= depolarization=excitatory=action potential. Open cl- channel= more negative going in, hyperpolarization. Diffusion is not a good means to take things long distances. Sodium is pumped back out through the atpase. It flows in the ion channel then is pumped out. Pumping out sodium is referred to as a repolarization.

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