BCMB 230 Lecture Notes - Lecture 18: Thoracic Cavity, Nitric Oxide, Sympathetic Nervous System
16 Dec 2016
School
Course
Professor
• Blood volume
• Venous vasoconstriction Increase venous return- Increase resistance, pressure flow
• Skeletal muscle pump- Buried in mumuscleMashed when constricted?Skeletal muscle
constriction pushes stuff through back to the heart. Apparent after sitting still long
periods of times. Feet swell. Especially bad for plane rides, deep vein thrombosis.
Spontaneous blood clot
• Respiratory pump- Heart and lungs in the same cavity- Thoracic cavity. Air into lungs,
blood into heart at the same time
• Miniimizizing ESV to increase SV
• “tarling’s La- Relationship betweeb stretch and contraction in cardiac muscle. Stretch
leads to more calcium, more cross bridges and a stronger contraction
• Contractility-An increase in contraction strength independent of stretch. Nerve or
hormone activity. (Sympathetic nerves and fight or flight response) Epinephrine
Norepinephrine. Decrease in contractility? Weak effect mentioned in book?
o S and C decrease ESV
• All of the aboe Preload
• Afterload- Increase ESV
(Figure 12.34))
Arteries- Move blood away from the heart
Heart--Arterials-Very small artery--- capillary--- venule back to vein
Capillary
Metabolic activity will make changes as it uses nutrients drop in oxygen, buildup of byproduct.
Acts on smooth muscle?
Need more oxygen because of this buildup
Flow autoregulation- Drop in pressure, Drop in flow
Drop in systemic pressure or blocked vessel somehow.
• Decrease in Oxygen
• Increase in metabolites
• Muscle relaxes, stretch decreases. Increase radius, decrease resistance more blood flow
• Figure 12.36
o Smooth muscle controlled by
▪ Nerves
• Sympathetic nerves
▪ Hormones
• Linked with kidney function. Epinephrine? Basoconstrictor and
Basodialator?
▪ Local factors
• Local stretch and chemical factors
• Nitric oxide, comes from neurons and endothelial cells which line
the blood vessels.
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Blood volume, venous vasoconstriction increase venous return- increase resistance, pressure flow, skeletal muscle pump- buried in mumusclemashed when constricted?skeletal muscle constriction pushes stuff through back to the heart. Apparent after sitting still long periods of times. Especially bad for plane rides, deep vein thrombosis. Spontaneous blood clot: respiratory pump- heart and lungs in the same cavity- thoracic cavity. Air into lungs, blood into heart at the same time: miniimizizing esv to increase sv, tarling"s la(cid:449)- relationship betweeb stretch and contraction in cardiac muscle. Stretch leads to more calcium, more cross bridges and a stronger contraction: contractility-an increase in contraction strength independent of stretch. Nerve or hormone activity. (sympathetic nerves and fight or flight response) epinephrine. Weak effect mentioned in book: s and c decrease esv, all of the abo(cid:448)e (cid:862)preload(cid:863, afterload- increase esv (figure 12. 34)) Heart--arterials-very small artery--- capillary--- venule back to vein. Metabolic activity will make changes as it uses nutrients drop in oxygen, buildup of byproduct.
