BIOL 160 Lecture Notes - Lecture 3: Nucleoside Triphosphate, Adenosine Triphosphate, Rna World

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17 Sep 2017
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Nucleotide - phosphate group + 5-c sugar + n-base. Ribonucleotides and deoxyribonucleotides both have -oh bonded to 3"c, but ribose has -oh on 2"c and deoxyribose has -h on 2"c. Pyrimidines - cytosine (c ), uracil (u)[rna], thymine (t)[dna] Nucleotides polymerize via condensation between -oh on sugar and p-group. Adenosine triphosphate (atp) - example of activated nucleotide. Only purine-pyrimidine combo fit inside the double helix. In a single strand of dna/rna one end has unlinked 5" phosphate and one end has unlinked 3" hydroxyl. Carries the info required for the organism"s growth and reproduction. Language of nucleic acids is contained in the sequence of bases. Nucleoside triphosphate are monomers used for synthesis of new dna strand. Presence of -oh group on ribose in rna makes it much more reactive and much less stable than dna. Structurally and chemically rna is intermediate between complexity of proteins.

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