BIOL 2100 Lecture Notes - Lecture 46: Lipid Bilayer, Apoptosis, Repressor
1 Dec 2016
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Document Summary
Cancer arises after an accumulation of mutations. Continuously have an activated growth signal, even without a growth factor. Ability to invade and grow throughout the body. Cancer cells require blood and can generate blood vessels. Cancer cells need almost all of the hallmarks in order to be a cancer cell. When a proto-oncogene becomes an oncogene, cells divide inappropriately. One base pair change can result in a mutation in ras that can cause a cell to continuously proliferate. Inversion in chromosomes can result in two genes fusing and produce a tyrosine kinase that is continuously dimerized. All components in the pathway that releases inhibitory proteins are considered tumor suppressors. Cancer cells can activate proteases to dissolve the cell matrix and break through tissue. Acquire skill and losing ability to be attached to neighbor. Cancer cells can induce synthesis of blood vessels to feed them. Highly regulated and can over-express stimulators or under-express.
