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Lecture 13

BIOL 3010 Lecture 13: Lecture 13

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BIOL 3010
Cronmiller Claire

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92616 Lecture 13 16:44 Transversion of AT (purine to pyrmidine) converts the base pair to CG orrrr TA Tautermoric shift of thymine causes transitions: MOST COMMON SOURCE OF DNA MUTATION!! 5bromouracil: structurally similar to thymine 2aminopurine: similar to adenine These two have mutagenic effect they undergo tautomeric effect more frequently than normal base pairs, causing more transitions Protonated tautomer of AP pairs with C 2 way transitions: base analogs dont cause transversions!! DNA reactive mutagens: cause changes in structure or chemical modifications but dont require replicating DNA Hydroxylamine: it can be increased, and if not broken down further it can cause damage; adds hydroxyl to amino nitrogen (cytosine) Tautomeric shift pairing with A instead of G GC> AT transitions CG> TA right? Hydroxyl amine only acts on C, so it cannot be reverted Alkylating agents: Electrophilic Add alkyl groups mostly methyl and ethyl groups most common target is guaninethymine It can cause structural damage, depurination Intercalating agents: Frameshift mutagens
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