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Lecture 13

BIOL 3010 Lecture 13: Lecture 13
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4 Pages
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Fall 2016

Department
Biology
Course Code
BIOL 3010
Professor
Cronmiller Claire
Lecture
13

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9/26/16 Lecture 13 16:44
Transversion of AT (purine to pyrmidine) converts the base pair to CG
orrrr TA
Tautermoric shift of thymine causes transitions: MOST COMMON SOURCE
OF DNA MUTATION!!
5-bromouracil: structurally similar to thymine
2-aminopurine: similar to adenine
These two have mutagenic effect- they undergo tautomeric effect more
frequently than normal base pairs, causing more transitions
Protonated tautomer of AP pairs with C
2 way transitions: base analogs don’t cause transversions!!
DNA reactive mutagens: cause changes in structure or chemical
modifications but don’t require replicating DNA
Hydroxylamine: it can be increased, and if not broken down further it can
cause damage; adds hydroxyl to amino nitrogen (cytosine)
Tautomeric shift pairing with A instead of G
GC-> AT transitions
CG-> TA right? Hydroxyl amine only acts on C, so it cannot be reverted
Alkylating agents:
Electrophilic
Add alkyl groups- mostly methyl and ethyl groups- most common target
is guanine/thymine
It can cause structural damage, depurination
Intercalating agents:
Frameshift mutagens
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Description
92616 Lecture 13 16:44 Transversion of AT (purine to pyrmidine) converts the base pair to CG orrrr TA Tautermoric shift of thymine causes transitions: MOST COMMON SOURCE OF DNA MUTATION!! 5bromouracil: structurally similar to thymine 2aminopurine: similar to adenine These two have mutagenic effect they undergo tautomeric effect more frequently than normal base pairs, causing more transitions Protonated tautomer of AP pairs with C 2 way transitions: base analogs dont cause transversions!! DNA reactive mutagens: cause changes in structure or chemical modifications but dont require replicating DNA Hydroxylamine: it can be increased, and if not broken down further it can cause damage; adds hydroxyl to amino nitrogen (cytosine) Tautomeric shift pairing with A instead of G GC> AT transitions CG> TA right? Hydroxyl amine only acts on C, so it cannot be reverted Alkylating agents: Electrophilic Add alkyl groups mostly methyl and ethyl groups most common target is guaninethymine It can cause structural damage, depurination Intercalating agents: Frameshift mutagens
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