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Lecture 6

BIOL 3010 Lecture 6: Lecture #6
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Department
Biology
Course Code
BIOL 3010
Professor
Cronmiller Claire

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Lecture #6 16:52
In order to find a trait we would have to find a difference. **We are
looking for variation
Hair color: determined by melasomes- melanin gives pigment, gives
the hair color.
Eurmelanin: contained in small granules oval in shape, dark in color
Pheomelanin: dusky colored melanin, more spherical, smaller than
eumelanin, light in color
Ratio of those two melanins determines hair color
How are these melanins synthesized?
Tyrosine is converted into the two. MC1R in the brain controls the ratio of
which pathway is produced more. In our population the pathway to
Eumelanin is favored
Blond hair can be almost any ratio but is consequence of BOTH being
reduced to reduced levels
It’s a complex trait, they are the sum accumulation of a lot different gene
functions occurring
How do genes do what they do?
Vast majority function through making a product and a mass majority of
regulation comes from regulation of transcription
1. mRNA: protein coding, messenger from transcription and carrying it to
ribosome
2. functional RNA’s:
transfer RNA: part DNA part polypeptide; functions as is- interprets mRNA
in translation
ribosomal RNA: structural, RNA and protein; rRNA, enzymatic RNA that
form polypeptide bond during translation
snRNA’s: snRNP-> functioning with splicesome, removing introns
microRNA: modulates whether or not that gene is transcribed or not
small interfering RNA: complementary to mRNA it can interfer and be
inhibitory on the level of transcription. They tend to be inhibitory on
whatever process they are coding
long noncoding RNA
DNA vs. RNA synthesis
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Description
Lecture #6 16:52 In order to find a trait we would have to find a difference. **We are looking for variation Hair color : determined by melasomes- melanin gives pigment, gives the hair color. Eurmelanin: contained in small granules oval in shape, dark in color Pheomelanin: dusky colored melanin, more spherical, smaller than eumelanin, light in color Ratio of those two melanins determines hair color How are these melanins synthesized? Tyrosine is converted into the two. MC1R in the brain controls the ratio of which pathway is produced more. In our population the pathway to Eumelanin is favored Blond hair can be almost any ratio but is consequence of BOTH being reduced to reduced levels It’s a complex trait, they are the sum accumulation of a lot different gene functions occurring How do genes do what they do? Vast majority function through making a product and a mass majority of regulation comes from regulation of transcription 1. mRNA: protein coding, messenger from transcription and carrying it to
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