BIOL 3010 Lecture Notes - Lecture 8: Exon, Intron, Polyadenylation

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In actuality most post transcription stuff is happening at the same time as transcription- co-transscriptional . Capping: adding cap nucleotide onto mrna, added onto all rna that go onto translation. Poly a tail: varying in length depending on length or mrna. Tfiih: associated with helicase but also functions enzymatically as a kinase which adds phosphates. Amino acids: they can all be primarily phosphorylated {cyronine, thymine, tyromine} These different amino acids may or may not be phosphorylated, they will show different patterns depending on the processing functioning that happens. The cap: specialized guanine getting added to 5" in response to ctd methylated the addition enzymes. The point is that this is not a static pattern: its dynamic. The change in phosphorylation in the ctd act differently with the different enzymes of the processes of these modifications (i. e. splicesome, poly a tail, capping, initiation) Splicing: generates diversity, different forms, only need one gene to produce slightly different proteins or overlapping chains.

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