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BIOL 3050 (2)
Lecture 1

BIOL 3050 Lecture 1: neurotransmitters:receptors

2 Pages
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Department
Biology
Course Code
BIOL 3050
Professor
Condron Barry

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Neurotransmitter
Post-synaptic Effect
Precursor(s)
Rate-limiting Step in
Synthesis
Removal Mechanism
Type of Vesicle
ACh (Acetylcholine)
Excitatory
Choline + acetyl CoA
CAT
AcHE-ase
Small + clear
Glutamate
Excitatory
Glutamine
Glutaminase
Transporters (EATT
pumps on glia)
Small + clear
GABA
Inhibitory
Glutamate
GAD
Transporters
Small + clear
Glycine
Inhibitory
Serine
Phosphoserine
Transporters
Small + clear
Catecholamines
(epinephrine,
norepinephrine,
dopamine)
Excitatory
Tyrosine
Tyrosine hydroxlase
Transporters ; MAO;
COMT
Small, dense-core ,
OR large irregular
dense-core
Serotonin (5-HT)
Excitatory
Tryptophan
Tryptophan
hydroxylase
Transporters; MAO
Large, dense-core
Histamine
Excitatory
Histidine
Histidine
decarboxylase
Transporters
Large, dense-core
ATP
Excitatory
ADP
Mitochondrial
oxidative
phosphorylation;
glycolysis
Hydrolysis to AMP
and adenosine
Small + clear
Neuropeptides
Excitatory & Inhibitory
Amino acids (protein
synthesis)
Synthesis and
transport
Proteases
Large, dense-core
Endocannabinoids
INHIBITS inhibition
Membrane lipids
Enzymatic
modification of lipids
Hydrolysis by FAAH
None
Nitric oxide
Excitatory & Inhibitory
Arginine
Nitric oxide synthase
Spontaneous
oxidation
None
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Description
Neurotransmitter Post-synaptic Effect Precursor(s) Rate-limiting Step in Removal Mechanism Type of Vesicle Synthesis ACh (Acetylcholine) Excitatory Choline + acetyl CoA CAT AcHE-ase Small + clear Glutamate Excitatory Glutamine Glutaminase Transporters (EATT Small + clear pumps on glia) GABA Inhibitory Glutamate GAD Transporters Small + clear Glycine Inhibitory Serine Phosphoserine Transporters Small + clear Catecholamines Excitatory Tyrosine Tyrosine hydroxlase Transporters ; MAO; Small, dense-core , (epinephrine, COMT OR large irregular norepinephrine, dense-core dopamine) Serotonin (5-HT) Excitatory Tryptophan Tryptophan Transporters; MAO Large
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