PSYS 216 Lecture Notes - Lecture 3: Buprenorphine, Phencyclidine, Partial Agonist
26 Jan 2018
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Dose for 50% of the drugs effect: efficacy- how effective a drug is at eliciting a response. 18. 8g: other kinds of dose-response curves, non-monotonic dose response curve, a curve that has both rising and falling phases, more is not always better, even independent of toxicity. Phencyclidine and ketamine and noncompetitive: partial agonist a receptor agonist that elicits a weaker. If all receptors are bound at plateau, and then introduce partial agonist, will bind to some receptors and illicit less of a response, reduce efficacy of drug: tolerance, a shift in the dose-response curve to the right. In tolerant subjects, the same does is less effective. In tolerant subjects, a greater dose required to produce the same effect: pharmacodynamic tolerance, cellular adaption to chronic drug use. Down regulation of receptor numbers or sensitivity: greater amount of drug needed to reach the same neural effect, pharmacokinetic tolerance, metabolic adaption to chronic drug use. Reduced heart-rate: some opiate withdrawal effects:
