BIOLOGY 151 Lecture Notes - Lecture 35: Cell-Mediated Immunity, Plasma Cell, Immunoglobulin Light Chain
Document Summary
Non-specific defense mechanisms- aka innate immunity: recognition of traits shared by broad ranges of pathogens, using a small set of receptors, rapid response, epithelial defenses. Contain lysozyme: breaks down cell walls of gram positive bacteria. Traps particles so cilia can push them up and out of the lung: inflammatory response viral replication. Response to physical injury or entry of microbes. Histamine, prostaglandin: released by mast cell (mast sends up red flag) Cause local capillaries to dilate and become more permeable: causes affected area to become red and hot, causes plasma to move into the tissue because fenestrations of capillaries are stretched out. Blood clotting agents leak into the tissue. Generally, recognize some portion of the outside of some pathogens. Especially effective against parasitic worms that are too large to be ingested. Secrete enzymes that make holes in the worm. Complex group of 20+ proteins that work together to lyse invading microbes: complement=the group of proteins.
