GENETICS 565 Lecture Notes - Lecture 2: Dna Repair, Noncoding Dna, Homologous Chromosome
Document Summary
Vietnam government estimates 4mil were exposed to the chemical, and 3mil were harmed (birth defects, severe chemical burns, etc. ) Promises on the horizon: genetic bases for diseases, traits, and behaviors will be understood, personal genetics analysis of your individual genes on an individual basis, pharmacogenetics/pharmacogenomics and personalized medicine. Professor believes that, even for single-gene diseases, we are making slow progress and need to think about how to analyze the information we already have rather than gather more. General comments about genetics and diseases: simple (single gene) vs complex diseases. What is the penetrance of the disease-causing allele? (what % of people with the specific allele have the disease phenotype, and to what severity?) What is the expressivity (severity of phenotype) of that allele: complex disease. Are their certain gene categories that need to be satisfied: simulating genetic disease is often done in model organisms (mice, flies, zebrafish, etc) and then correlated with human genetic findings.
