GENETICS 155 Lecture Notes - Lecture 1: Fragile X Syndrome, X-Inactivation, Rett Syndrome
12 Dec 2017
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Normal variations in genome-wide dna methylation (epigenetics) by reid alisch. Heritable traits that don"t involve differences in underlying dna sequence. Vitamin b12 or folic acid changed mice colors. Two main components of epigenetic code: dna methylation, histone modification. A complex etiology for the autism spectrum disorders: (asd) Twin and family studies strongly support a genetic contribution for the autism spectrum disorders. Asd associates with gene disorders having an epigenetic etiology. Most common cytogenetic abnormality in asd involves an imprinted region-- maternal. Hypermethylation of the oxytocin receptor in autism. Utilize a genome-wide dna methylation platform to interrogate changes in dna methylation associated with health and disease. Characterize normal variations of dna methylation (e. g. age) that act as covariates in. Correct for covariates in our data to determine if there is a unique dna methylation profile disease-based dna methylation studies associated with health and disease. Bead-bound probes for methylation detection at 27,578 cpg dinucleotides (~0. 1% of genome)
