ZOOLOGY 651 Lecture Notes - Lecture 22: Assortative Mating, Wood Frog, Coefficient Of Relationship

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Breeding practices that increase the physical expression of rare genetic traits through intentional inbreeding has been linked with abnormal, debilitating, and at times, lethal, external and internal conditions and characteristics. Only 2 left pup, mom, and dad (and granddad) inbred. Sibs and father and daughter spinal malformations increase in small populations inbreeding effects accumulate over time. Genetic hazards in small populations: inbreeding depression. Has immediate and cumulative effects genetic drift fixation of deleterious mutations can cause mutational meltdown loss of quantitative genetic variation genetic swamping from other populations interactions among these forces. How do we measure inbreeding? estimate f from the deficiency of heterozygotes in a population relative to what is expected (from h-w) F = 1 - (hetobs/hetexp) can estimate inbreeding for: individuals - based on pedigrees (ancestry) individuals - from heterozygosity in snp data sub-populations relative to the total population: f-st inbreeding coefficient.

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