BIOLOGY 253 Lecture Notes - Lecture 10: Microtubule Organizing Center, Intermediate Filament, Vimentin
13 Jan 2017
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Document Summary
Goal 1: recognize and recall the functions of microtubules, microfilaments, and intermediate filaments in a cell. Goal 2: discuss how cytoskeleton can change or be organized differently in a cell. Goal 3: apply our understanding of microfilament growth and shrinkage to cell migration and metastasis. Goal 4: apply our understanding of microtubule growth and shrinkage to cell division. Goal 5: evaluate how chemotherapeutic drugs target cytoskeleton. Goal 6: analyze and interpret experimental data involved in these processes. Goal 7: review the basic events that occur in the cell cycle (mitosis) Intermediate: very flexible and very strong, used for structural support, cell connections and nuclear membrane (hair and nails example) Microtubules: rigid, break when stretched, organized in growing centrosome, Actin: very flexible, in cortex of cell, necessary for cell migration. Heterogeneous, great tensile strength, no polarity, do not bind nucleotides (no interaction with atp and.
