BIOL 151 Lecture Notes - Lecture 14: Dna Replication, Transposable Element, Nucleosome

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3 Apr 2017
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Biol 151 chapter 13: 1 genome sequencing. Complete genome sequences are assembled from smaller pieces: to sequence a whole genome, a large number of dna fragments sequence any particular small region of the genome 10-50 times. Sequence assembly: the short sequences are put together in the correct order to generate the long, continuous sequence of nucleotides in the dna molecule present in each chromosome. Shotgun sequencing: when the sequence fragments do not originate from a particular gene or region but from sites scattered randomly across the chromosome. Sequences that are repeated complicate sequence assembly: the repeated sequence may be several thousand nucleotides long and present in multiple identical or nearly identical copies. Personalized medicine: an individual"s genome sequence, by revealing his/her disease susceptibilities and drug sensitivities, allows treatments to be tailored to the individual. Genome annotation identifies various types of sequence: genome annotation: the process by which researches identify the various types of sequence present in genomes.

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