BIOL 3134 Lecture Notes - Lecture 8: Human Genome Project, Craig Venter, Celera Corporation

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2 Jan 2020
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Human genome: 3 billion base pairs, contains about 20,000 coding genes. Human genome project: 1988: us congress authorized the billion, 15-year project, 1990: project began (directed by dr. james watson) Genome sequence technology: early 1970s, no way to directly determine the order of nucleotides in a gene, mid 1970s, walter gilbert, frederick sanger, developed sequencing techniques, 1980: gilbert and sanger won nobel prize. Sanger sequencing: uses dna polymerase to synthesize labeled dna strands of different sizes. Human genome project the competitor: 1998: celera genomics (directed by dr. craig venter) International consortium was too slow and expensive: million, around 3 years, would not permit free redistribution or scientific use, sought for patent using dna sequences. Next generation sequencing: uses smaller (100bp) fragments of dna. Large numbers of sequences can be analyzed in parallel: requires large amount of computer analysis. Transposon: repeat sequence derived mostly from viruses, sine (alu) sequence 300 bp (10% of our genome)

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